Sunday, 16 June 2019

PCSK9 inhibitors: Studies needed to prove efficacy and safety in chronic kidney disease

Chronic kidney disease (CKD) is associated with a substantially increased risk for the development of atherosclerotic cardiovascular disease (CVD). Accordingly, cardiovascular mortality is increased even in the earliest stages of CKD. In the general population and in CKD patients, high plasma levels of low-density lipoprotein cholesterol (LDL-C) are crucially involved in the initiation and progression of atherosclerotic vascular lesions. In addition, it has been documented that LDL accumulating in the vascular wall is prone to be post-translationally modified, for example, by oxidation or carbamylation, which is particularly relevant to patients with CKD.

* This article was originally published here

Are transgender men and women who take hormones at risk for heart disease?

The impact of hormone therapy on the heart health of transgender men and women has been the subject of several studies published within the last year. But medical experts and researchers aren't ready to sound the alarm just yet.

* This article was originally published here