A single dose of the main psychoactive component in cannabis, tetrahydrocannabinol (THC), can induce a range of psychiatric symptoms, according to results of a systematic review and meta-analysis of 15 studies including 331 people with no history of psychotic or other major psychiatric disorders, published in The Lancet Psychiatry journal.
source https://www.lifetechnology.com/blogs/life-technology-medical-news/single-dose-of-thc-could-induce-psychotic-depressive-and-anxiety-symptoms-in-healthy-people