Native American use of galena at Kincaid Mounds, a settlement occupied during the Mississippian period (1150 to 1450 CE), resulted in more than 1.5 metric tons of lead pollution deposited in a small lake near the Ohio River. New data from IUPUI researchers found the lead did not originate from this Southern Illinois settlement, but instead was brought to the site from other Midwest sources.
source https://www.lifetechnology.com/blogs/life-technology-science-news/lead-pollution-from-native-americans-attributed-to-crushing-galena-for-glitter-paint