French investigators have described development of resistance to one of the last resort therapies used to treat extremely drug-resistant Pseudomonas aeruginosa. That resistance arose in a single patient over a scant 22 days. They subsequently identified the single nucleotide mutation in P. aeruginosa that caused the resistance. The research is published in Antimicrobial Agents and Chemotherapy, a journal of the American Society for Microbiology.
source https://www.lifetechnology.com/blogs/life-technology-medical-news/resistance-to-last-resort-drug-arose-in-patient-over-3-weeks